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Fosaprepitant dimeglumine
CAS No. 265121-04-8
Fosaprepitant dimeglumine( MK 0517 )
Catalog No. M13812 CAS No. 265121-04-8
Fosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 41 | In Stock |
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| 10MG | 55 | In Stock |
|
| 25MG | 111 | In Stock |
|
| 50MG | 201 | In Stock |
|
| 100MG | 332 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameFosaprepitant dimeglumine
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NoteResearch use only, not for human use.
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Brief DescriptionFosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.
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DescriptionFosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.(In Vitro):Fosaprepitant dimeglumine (30 mg/kg; i.p.; daily; for 7 days) attenuates tolerance to morphine and increases the antinociceptive effect in in rats.
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In Vitro——
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In VivoAnimal Model:Sprague-Dawley rats Dosage:30 mg/kg Administration:Intraperitoneal injection, daily, for 7 days Result:Increased the antinociceptive effect of morphine compared to control group.
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SynonymsMK 0517
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PathwayGPCR/G Protein
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TargetNeurokinin Receptor
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RecptorNK1
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number265121-04-8
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Formula Weight1004.83
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Molecular FormulaC37H56F7N6O16P
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Purity>98% (HPLC)
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SolubilityWater: 135 mg/mL (134.35 mM); DMSO: 201 mg/mL (200.03 mM)
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SMILESC[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)N(N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Navari RM. Expert Opin Investig Drugs, 2007, 16(12), 1977-1985.
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