Fosaprepitant dimeglumine ( MK 0517 )

Catalog No. M13812 CAS No. 265121-04-8

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Product Name

Fosaprepitant dimeglumine
Note

Research use only, not for human use.
Brief Description

Fosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.
Description

Fosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.
Synonyms

MK 0517
Pathway

GPCR/G Protein
Target

Neurokinin Receptor
Recptor

NK1
Research Area

Neurological Disease
Indication

——

CAS Number

265121-04-8
Formula Weight

1004.83
Molecular Formula

C37H56F7N6O16P
Purity

>98%(HPLC)
Solubility

Water: 135 mg/mL (134.35 mM); DMSO: 201 mg/mL (200.03 mM)
SMILES

C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)N(N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
Chemical Name

——

1.Navari RM. Expert Opin Investig Drugs, 2007, 16(12), 1977-1985.

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